Présentation du Dr Benveniste
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CURRICULUM VITAE
Name : BENVENISTE First name : Jacques Date and place of birth : 12 March 1935, 75009 Paris, France Marital status : Married, 5 children
ACADEMIC CURRICULUM
Baccalauréat, 1951 Medical study at Faculté de Médecine de Paris, 1953-1960
University degrees :
Medical doctor, Faculté de Médecine de Paris, Thesis silver medal, 1967 Chef de Clinique, Faculté de Médecine de Paris, 1967-1969
Hospital titles :
Externe des Hôpitaux de Paris, 1956 Interne des Hôpitaux de la Région de Paris, 1959 Interne des Hôpitaux de Paris, 1961 Assistant des Hôpitaux de Paris, 1967
RESEARCH POSITIONS
Part-time researcher at Institut de Recherche sur le Cancer, CNRS, Villejuif (Dr. J.C. Salomon and Prof. W. Bernhardt), 1965-1969 Research Associate, Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California (Drs C.G. Cochrane and F.J. Dixon), 1969-1972 (Fellowship from International Center for Research on Cancer) Chargé de Recherches, INSERM Unit 25, Hôpital Necker, Paris, 1973 Head of the Research Laboratory on Immediate Hypersensitivity and Immunopathology, INSERM Unit 25, 1977 Directeur de Recherche 2ème Classe INSERM, INSERM Unit 131, Clamart, 1978 Head of INSERM Unit 200 : Immunology of Allergy and Inflammation, Clamart, 1980 Directeur de Recherche 1ère Classe INSERM, 1984 Head of Digital Biology Laboratory, Clamart, 1995
MAIN SCIENTIFIC ACHIEVEMENTS
Discovery of "Platelet-Activating Factor", 1970 Author of the controversial article on the "memory of water", Nature, 1988, which lead to the recent development of Digital Biology.
Jacques BENVENISTE - Selected publications*
BENVENISTE J, HENSON PM, COCHRANE CG : Leukocyte-dependent histamine release from rabbit platelets : the role of IgE, basophils and a platelet-activating factor. J EXP MED, 1972, 13:1356-1377.**
BENVENISTE J : Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils. NATURE, 1974, 249:581-582.
BENVENISTE J, LE COUEDIC JP, POLONSKY J, TENCE M : Structural analysis of purified platelet-activating factor by lipases. NATURE, 1977, 269:170-171.
CHIGNARD M, LE COUEDIC JP, TENCE M, VARGAFTIG BB, BENVENISTE J : The role of platelet-activating factor in platelet aggregation. NATURE ,1979, 279:799-800.
BENVENISTE J, TENCE M, VARENNE P, BIDAULT J, BOULLET C, POLONSKY J : Semi-synthèse et structure proposée du facteur activant les plaquettes (PAF) : PAF-acéther, un alkyl éther analogue de la lysophosphatidylcholine. C R ACAD SCI PARIS, 1979, 289, série D:1037-1040.**
CHAP H, MAUCO G, SIMON MF, BENVENISTE J, DOUSTE-BLAZY L : Biosynthetic labelling of platelet-activating factor (paf-acether) from radioactive acetate by stimulated platelets. NATURE, 1981, 289:312-314.
DAVENAS E, BEAUVAIS F, AMARA J, OBERBAUM M, ROBINZON B, MIADONNA A, TEDESCHI A, POMERANZ B., FORTNER P, BELON P, SAINTE-LAUDY J, POITEVIN B, BENVENISTE J : Human basophil degranulation triggered by very dilute antiserum against IgE. NATURE, 1988, 333-816-818.
BENVENISTE J, DAVENAS E, DUCOT B., CORNILLET B., POITEVIN B, SPIRA A : L’agitation de solutions hautement diluées n’induit pas d’activité biologique spécifique. C R ACAD SCI PARIS,1991,312,série II:461-466.
BEAUVAIS F, SHIMAHARA T, INOUE I, BENVENISTE J : Anti-IgE induces the opening of non selective cation channels on human basophils. FUNDAM CLIN PHARMACOL, 1994, 8:246-250.
NGUER CM, PELLEGRINI O, GALANAUD P, BENVENISTE J, THOMAS Y, RICHARD Y : Regulation of paf-acether receptor expression in human B cells. J IMMUNOL, 1992, 149:2742-2748.
CALABRESSE C, NGUER CM, PELLEGRINI O, BENVENISTE J, RICHARD Y, THOMAS Y : Induction of high-affinity paf-acether receptor expression during T cell activation. EUR J IMMUNOL, 1992, 22:1349-1355.
BEAUVAIS F, HIEBLOT C, BURTIN C, BENVENISTE J : Regulation of human basophil activation. III. Impairment of the inhibitory effect of Na+ on IgE-mediated histamine release in patients with allergic rhinitis. J ALLERGY CLIN IMMUNOL, 1992, 90:52-58.
BEAUVAIS F, HIEBLOT C, BURTIN C, BENVENISTE J : Regulation of human basophil activation. IV. Dissociation between cationic dye binding and histamine release : role of Ca2+ ions. FUNDAM CLIN PHARMACOL, 1992, 6:153-158.
EL AZZOUZI B, JURGENS P, BENVENISTE J, THOMAS Y : Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature human T cell line. BIOCHEM BIOPH RES COMMUN, 1993, 190:320-324.
BIDET B, LEBOYER M, DESCOURS B, BOUVARD MP, BENVENISTE J : Allergic sensitization in infantile autism. J AUTISM DEVELOP DISORD, 1993, 23:419-420.
PELLEGRINI O, DAVENAS E, MORIN L, BENVENISTE J, MANUEL Y, THOMAS Y : Stress proteins in human lymphocytes. II. Modulation of stress proteins in a human T cell line. EUR J PHARMAC, 1994, 270:221-228.
EL AZZOUZI B, TSANGARIS G, PELLEGRINI O, BENVENISTE J, MANUEL Y, THOMAS Y : Cadmium induces apoptosis in a human T cell line. TOXICOLOGY, 1994, 88:127-139.
HILLIQUIN P, NATOUR J, AISSA J, GUINOT P, LAOUSSADI S, BENVENISTE J, MENKES CJ, ARNOUX B : Treatment of carrageenan-induced arthritis by platelet-activating factor (paf) antagonist BN 50730. ANN RHEUM DIS, 1995, 54:140-143.
HILLIQUIN P, HARRAN H, AISSA J, BENVENISTE J, MENKES CJ : Correlations between paf-acether and tumor necrosis factor in rheumatoid arthritis. SCAND J RHEUM, 1995, 24:169-173.
GUIMBAUD R, IZZO A, MARTINOLLE JP, VIDON N, COUTURIER D, BENVENISTE J, CHAUSSADE S : Intraluminal excretion of paf, lysopaf, and acetylhydrolase in patients with ulcerative colitis. DIGEST DIS SCI, 1995, 40:2635-2640.
KORTH RM, HIRAFUJI M, BENVENISTE J, RUSSO-MARIE F : Human umbilical vein endothelial cells : specific binding of platelet-activating factor and cytosolic calcium flux. BIOCHEM PHARMAC, 1995, 49:1793-1799.
AÏSSA J, HARRAN H, RABEAU M, BOUCHERIE S, BROUILHET H, BENVENISTE J : Tissue levels of histamine, paf-acether and lysopaf-acether in carrageenan-induced granuloma in rats. INT ARCH ALLERGY IMMUNOL, 1996, 110:182-186.
* From about 300, including 26 publications in J IMMUNOL from 1971 to 1994
** CURRENT CONTENTS "Citation Classic".
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